February 14, 2018
Industries that discharge wastewater into receiving aquatic environments are often required to perform direct toxicity assessment (DTA) of their discharges. This usually involves exposing live aquatic animals to discharge water, and measuring responses such as development, reproduction and survival. However, these assays have ethical considerations, long exposure times (4-10 days), are dependent on animals being available (either from lab cultures or field collection), and are expensive to run. Cell-based assays can provide an ethical alternative to live animal testing that is high throughput, cost-effective, indicative of live animal responses, and readily available once established in a laboratory.
The initial phase of this project (Phase 1) is presented in this final report, and focused on regulator acceptance of incorporation of in vitro bioassays into DTA programs by:
Phase 1 culminated in a workshop in which researchers, regulators and industry representatives discussed the findings of the Milestone reports, and developed a strategy for developing a suite of in vitro bioassays for inclusion in DTA programs in Australia (Phase 2).
You can access the final report from the project webpage - but log in first!
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